Postdoctoral Position in Basal Ganglia Electrophysiology and Deep Brain Stimulation As a leading university hospital with a rich tradition, the Inselspital is part of the Insel Group and is a centre of medical expertise and high technology with an international reputation as well as being a first-class training and research centre. Postdoctoral Position in Basal Ganglia Electrophysiology and Deep Brain Stimulation Department of Neurology Movement disorders centre 100 % | in Bern Starting 01.02.2019 or after agreement 1-year with possibility of prolongation Deep brain stimulation (DBS) is an established treatment for Parkinson's disease and other movement disorders. This therapy however is limited by a slow manual and error-prone programming approach to identify the optimal stimulation site and by stimulation-induced side effects. Electrophysiological recordings from the basal ganglia, the structures where the electrodes are implanted, revealed the presence of signal patterns that are related to clinical symptoms. Studying distribution and characteristics of these biomarkers led to the first pilot studies toward automatized DBS programing and closed-loop DBS. At the University Hospital Bern around 40 DBS surgeries are performed annually in patients with movement disorders. Intraoperative local field potentials (LFPs) are recorded regularly from directional DBS leads with the aim to understand the pathophysiological signature of basal ganglia signals that best reflect clinical symptoms and DBS outcome. The challenge The goal of the current research project is to adapt existing, and develop new LFP-based algorithms, to optimize and automatize the postoperative DBS programming. This involves the processing of a large existing data set of basal ganglia LFPs, application of statistical signal analyses and machine learning to explore the anatomical/electrophysiological relationship during rest and motor tasks and to predict the clinical response to DBS. The applicant will also participate in data recording and implementation of closed-loop DBS experiments. The candidate will be supervised and work closely with Dr. Tinkhauser within the Movement Disorders Group and in collaboration with neurologists, neurosurgeons and engineers. Your profile The successful applicant will hold or be close to completing a PhD in neuroscience or quantitative discipline (e.g. engineering, physics). Essential skills include experience in electrophysiological signal (e.g. EEG, LFP) processing and analysis, machine learning, proficiency in programming (particularly Matlab), good interpersonal, oral and written communication skills. You will be highly self-motivated; able to problem-solve and trouble-shoot technical difficulties; The package Literature references Oscillations and the basal ganglia: motor control and beyond JS Brittain, P Brown Neuroimage 85, 637-647 Directional local field potentials: A tool to optimize deep brain stimulation. Tinkhauser G, Pogosyan A, Debove I, Nowacki A, Shah SA, Seidel K, Tan H, Brittain JS, Petermann K, di Biase L, Oertel M, Pollo C, Brown P, Schuepbach M; Mov Disord. 2018 Jan;33(1):159-164. The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease Tinkhauser, G, Pogosyan A, Little S, Beudel M, Herz DM, Tan H, Brown P; Brain. 2017 Apr 1;140(4):1053-1067 Electrophysiological differences between upper and lower limb movements in the human subthalamic nucleus. Tinkhauser G, Shah SA, Fischer P, Peterman K, Debove I, Nygyuen K, Nowacki A, Torrecillos F, Khawaldeh S, Tan H, Pogosyan A, Schuepbach M, Pollo C, Brown P; Clin Neurophysiol. 2019 May;130(5):727-738. Please only apply online. Contact For further details please contact: Regina Erpen, Secretariat Center for Movement Disorders Telephone: +41 31 664 03 71 Your application Please only apply online.